adjoining tissue, some sort of neurogenesis, or brain repair, might take place? And could such neurogenesis be stimulated ?
So relatively little is known of the human brain, after so manymillennia! The brain is the only organ whose functions must be theorized from observed behavior, and whose basic physiology is scarcely comprehended at the present timeâthat is, 1965. Only animal brains can be examined âliveââprimarily monkey brains. Invasive exploration of the (living, normal) human brain is forbidden. Margot wonders: Are complex memories distributed throughout the cerebral cortex, or localized?âand if localized, how? From what is known of E.H.âs brain, the hippocampus and adjacent tissue had been devastated by the viral infectionâbut have other parts of the brain remained unimpaired? Unless E.H. undergoes brain surgery, Margot thinks, or sophisticated scanning machines are developed to âX-rayâ the brain, it isnât likely that the precise anatomy of E.H.âs brain will be known until after his death when the brain can be autopsied.
In that instant Margot feels a glimmer of horror, and excitement. She sees E.H. on a marble slab in a morgue: a corpse, skull sawed open. The pathologist will remove the brain that will be fixed, sectioned, stained, examined and analyzed by the neuroscientist.
She will be the neuroscientist.
E.H. glances worriedly at her as if he can read her thoughts. Margot feels her face burn like one who has dared to touch another intimately, and has been detected.
But I will be your friend, Mr. Hoopes!âEli.
I will be the one you can trust.
âUnlocking the mystery of memoryââMargot Sharpe will be among the first.
With an uplifted forefinger, to retain Margotâs attention, E.H. leafs through his little notebook in search of something significant. In his bright affable voice he reads:
ââThere is no journey, and there is no path. There is no wisdom, there is emptiness. There is no emptiness.ââ He pauses to add, âThis is the wisdom of the Buddha. But there is no wisdom, and there is no Buddha.â He laughs, with inexplicable good humor.
His examiners stare at him, unable to join in.
TESTING RESUMES. E.H. appears eager again, hopeful.
It is hard to comprehend: to the subject, the morningâs adventure is only now beginning. He has forgotten that he is âtired.â
Like appetite, âtirednessâ depends much upon memory. Margot would not have believed this could be soâit seems unnatural!
A scientist soon learns: much in Nature is âunnatural.â
At this midpoint Milton Ferris departs. He has an appointmentâa luncheon perhaps. The principal investigator entrusts his assistants to run the tests he has designed without his supervision.
Margot follows instructions diligently: even when she knows what to do next she waits for Alvin Kaplan, Ferrisâs protégé, to instruct her. Testing E.H. is laborious, repetitive, yet fascinatingâmemory tests of various kinds, auditory and visual, of gradually increasing complexity.
One of the tests seems purposefully designed to frustrate and discourage the subject. E.H. is instructed by Kaplan to count âas high as you can without stopping.â E.H. begins counting and continues for an impressively long time, beyond seventy seconds; his counting is methodical, by rote. Then, at numeral eighty-nine, Kaplan interrupts, distracting E.H. by showing him a card with an elaborate geometrical design E.H. is asked to describeââLooks like three pyramids upside down or maybeâpineapples?â
And now when Kaplan asks E.H. to continue with his counting, E.H. is utterly baffled. He has no idea how to proceed.
ââCountingââwhat? What was I âcountingâ?â
âYou were counting numbers âas high as you canââthen you stopped to describe this card. But now, Eli, you can