Almost immediately, the passage was reviewed for grammar by The New Yorker ’s grammarian, a quiet person named Ann Goldstein. (Experts who are being quoted in The New Yorker are encouraged not to use bad grammar.)
Minutes later, with Bill Close still waiting on the telephone, we heard that his grammar was okay, and we heard that the magazine had been transmitted electronically to the printing plant. I said good night to the now-eponymous Dr. Close and hung up.
That was when something struck me. How could I have been so stupid? I had forgotten to ask Close what had happened to the Belgian doctor afterward. He would have died a grisly death. Years later, I learned what had transpired, and you will read it here.
In “The Human Kabbalah,” I explored the decoding of the human DNA and the resulting fantastic stock-market bubble that made the genomic scientist J. Craig Venter a billionaire for a while. One day, while working on this story, I was hanging out in the laboratory of the Nobel laureate Hamilton O. Smith—one of the great figures in the history of molecular biology—and I mentioned to him that I was having trouble, as a writer, describing DNA in a physical sense. I wanted readers to get a concrete picture of it in their minds. “The trouble is, DNA is invisible,” I said to Hamilton Smith.
“No, it isn’t,” he said. He asked me if I’d ever seen it. I hadn’t, so he dribbled some purified DNA out of a test tube. It looked like clear snot.
“What does it taste like?” I asked him.
That surprised him a little. He didn’t know. In almost forty years of research with DNA, Hamilton Smith had never tasted the molecule.
As soon as I got home, I ordered some pure, dried DNA through the mail. It arrived: a bit of fluff in a bottle. I put some of it on my tongue. Sure enough, it had a taste. In taking notes, it is useful to remember that all the senses can be involved.
I continued to follow the Chudnovsky brothers and their journeys in the universe of numbers. This led them, with me trailing behind, to the mysterious Unicorn Tapestries, owned by the Metropolitan Museum of New York. All the while, I was researching the curious genetic disease that causes people to mutilate and even, in effect, cannibalize their own bodies—Lesch-Nyhan syndrome.
The disease was almost unbearable to contemplate, and at first almost impossible to describe. It made its victims seem inhuman. I couldn’t find a way into the writing of the story, despite spending months and finally years on it. Ultimately, the last chapter of this book took me seven years to write. The disease probably could not be invented by a fiction writer, or if it were invented, it would not seem believable. Yet there it was, an undeniable reality. I needed to understand, if possible, what it might feel like to have this disease. I wanted to try to connect the seemingly unknowable experience of self-cannibalism to that of common humanity. Henry Fielding, in his famous preface to his novel The History of Tom Jones, in which he defined the basic terms of fiction writing, quoted Terence: “I am human: nothing human is alien to me.” If people with Lesch-Nyhan disease were human, then they could not be alien to us. The only way to find humanity in the story was to climb into the soup with two people who had been born with the disease and start taking notes.
The Mountains of Pi
W HEN HE WAS THIRTY-SIX , Gregory Volfovich Chudnovsky began to build a supercomputer in his apartment from mail-order parts. Gregory Chudnovsky was a number theorist, a mathematician who studies numbers, and he felt that he needed a supercomputer to do it. His apartment was situated near the top floor of a run-down building at the corner of 120th Street and Amsterdam Avenue, on the West Side of Manhattan. Around the time he decided to build the supercomputer, a corpse was found stuffed into a garbage can at the end of his block. The project officially took two years, though in